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What Is CD8 Antibody?

What Is CD8 Antibody?

The CD8 beta antibody is an effective marker for cytotoxic lymphocytes. It binds to the CD8 coreceptor on the cell surface and recognizes the topological domain in CD8 alpha. This CD8 antibody recognizes both the CD8 beta heterodimer (the most common), and the CD8 alpha – CD8 b homodimer (the least common). Natural killer cells (NK cells), cortical, and thymocytes also express the CD8A gene.

The CD8A antibody could be used as a marker for these cells. The CD8 molecule is made up of two chains, alpha, and beta. CD8 can be found on T cells of normal cytotoxic/suppressor cells, which account for approximately 20 to 35% of human peripheral blood lymphocytes. You can know more about CD8 antibodies via

Natural killer cells (80% of thymocytes) also detect the CD8 antigen. They are a subpopulation (30% of peripheral blood null cells and 15-30% of bone marrow cells). CD8 + T cells recognize immunogenic peptides present at the cell surface-bound by major histocompatibility class I (MHCI). Antigen recognition is achieved by binding both the T-cell receptor (TCR) and the CD8 co-receptor (pMHCI) to the same peptide -MHCI (MHC). 

The TCR determines the specificity, while CD8 has an effect on antigen sensitivity. To examine the role of CD8 in CD8 + cell activation, anti-CD8 antibodies were extensively used. However, previous studies have shown conflicting results and it is not clear whether anti-CD8 antibody per se can induce effector function. 

OKT8 also increased TCR/pMHCI rates and could therefore be used to enhance pMHCI staining and visualization of antigen-specific T-cells CD8 +. Despite having opposite effects on pMHCI tetramer stained, the anti-mouse CD8 antibody CT-CD8a/CT-CD8b also activated CD8 + T cells. Anti-CD8 antibodies are capable of activating T-cell effector functions in a heterogeneous manner. 

Mary Mack